达比加群酯治疗癌症患者PICC导管相关上肢静脉血栓形成的疗效和安全性 |
| 何昱贤 喻诗雄 |
| 重庆医科大学附属第二医院，重庆，400060 |
| 摘要：目的? 本研究旨在评估达比加群酯和依诺肝素钠在癌症患者置入经外周置入中心静脉导管（PICC）后出现导管相关上肢深静脉血栓（UEDVT）的治疗中的疗效及安全性。方法? 本研究共纳入81例癌症患者出现PICC相关UEDVT的患者，其中41例接受达比加群酯治疗，40例持续依诺肝素钠治疗，比较两组患者的复发性静脉血栓栓塞（VTE）及出血事件发生率。结果? 两组患者基线特征无显著差异。达比加群酯组复发性VTE发生率为2.5%，依诺肝素钠组为0（P=0.160），所有复发性VTE事件均未进展；两组均未发生大出血，临床相关非重度出血事件发生率分别为9.8%和5.0%（P=0.409）。结论? 达比加群酯疗效和安全性与依诺肝素钠相当，可作为口服替代选择，远期效果需验证。 |
| 关健词：达比加群酯；导管相关性静脉血栓形成；抗凝治疗；经外周置入中心静脉导管 |
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| Efffcacy and Safety of Dabigatran Etexilate in the Treatment of PICC Catheter-Related Upper Extremity Venous Thrombosis in Cancer Patients |
| Yuxian He Shixiong Yu |
| The Second Afffliated Hospital of Chongqing Medical University, Chongqing 400060，China |
| Abstract：Objective This study aims to evaluate the efffcacy and safety of dabigatran etexilate and enoxaparin sodium in the treatment of catheter-related upper extremity deep vein thrombosis (UEDVT) in cancer patients after the insertion of a peripherally inserted central catheter (PICC). Methods A total of 81 cancer patients with PICC-related UEDVT were included in this study. Among them, 41 patients received dabigatran etexilate treatment, and 40 patients continued enoxaparin sodium treatment. The incidences of recurrent venous thromboembolism (VTE) and bleeding events were compared between the two groups.Results There were no signiffcant differences in the baseline characteristics between the two groups. The incidence of recurrent VTE in the dabigatran etexilate group was 2.5%, and it was 0 in the enoxaparin sodium group (P=0.160). All recurrent VTE events did not progress. No major bleeding occurred in either group. The incidences of clinically relevant non-major bleeding events were 9.8% and 5.0% respectively (P=0.409). Conclusion The efffcacy and safety of dabigatran etexilate are comparable to those of enoxaparin sodium. It can be used as an oral alternative, but its long-term effects need to be veriffed. |
| Keywords：Dabigatran etexilate; Catheter-related venous thrombosis; Anticoagulant therapy; peripherally inserted central catheters |
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