以半夏泻心汤为主方加减治疗慢性萎缩性胃炎的临床有效率评价 |
| 赵燕明 |
| 北京紫竹桥中医医院, 北京，100049 |
| 摘要：目的 探讨慢性萎缩性胃炎临床治疗中应用以半夏泻心汤为主方加减治疗的效果与价值。方法 观察对象为80例前来我院就诊的慢性萎缩性胃炎患者，收集时间为2021年8月至2025年6月，依照随机数字表法将其分成两组，40 例设定为对照组，本组予以常规西药治疗，40 例设定为研究组，本组的西药治疗方式与对照组相同，同时予以以半夏泻心汤为主方加减治疗，两组患者就临床症状积分改善情况、治疗效果、血清炎症因子水平变化、胃黏膜组织病理评分、不良反应发生率等展开统计比较。结果 两组之间进行比较，治疗前嗳气、胀满、脘腹痛等临床症状积分及IL-6、IL-8、TNF-α等血清炎症因子水平及胃黏膜组织病理评分的差异并不大，无统计学意义，P ＞ 0.05；治疗后，研究组临床症状积分、血清炎症因子水平及腺体萎缩、活动度、异型增生黏膜炎症、肠上皮化生等胃黏膜组织病理评分全部低于对照组，且全部存在统计学差异，P ＜ 0.05；研究组患者的临床治疗总有效率较对照组高，同时其不良反应发生率较对照组低，组间出现的差异具备统计学意义，P ＜ 0.05。结论 选择以半夏泻心汤为主方加减治疗的方式有利于快速改善慢性萎缩性胃炎患者的临床症状与胃黏膜组织病理状态，同时进一步降低炎症因子的影响，切实提高临床疗效与安全性，值得作为理想的治疗方法在临床中积极推广。 |
| 关健词：慢性萎缩性胃炎；半夏泻心汤；常规西药 |
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| Clinical efficacy evaluation of modified Banxia Xiexin Tang in thetreatment of chronic atrophic gastritis |
| Yanming Zhao |
| Beijing Zizhuqiao Traditional Chinese Medicine Hospital, Beijing 100049 , China |
| Abstract: Objective To explore the effect and value of modified Banxia Xiexin Tang as the main formula in the clinicaltreatment of chronic atrophic gastritis. Methods The observation subjects were 80 patients with chronic atrophic gastritis whocame to our hospital for treatment from August 2021 to June 2025. They were randomly divided into two groups according tothe random number table method, with 40 cases as the control group and 40 cases as the study group. The Western medicinetreatment method in this group was the same as that in the control group, and the main formula was Banxia Xiexin Tang withmodifications. The two groups of patients were statistically compared in terms of clinical symptom score improvement, treatmenteffect, changes in serum inflammatory factor levels, gastric mucosal histopathological score, and incidence of adverse reactions.Result There was no significant difference in clinical symptom scores such as belching, bloating, and abdominal pain,as well as serum inflammatory factor levels such as IL-6, IL-8, TNF - α, and gastric mucosal histopathological scores betweenthe two groups before treatment, P＞ 0.05； After treatment, the clinical symptom scores, serum inflammatory factor levels, andpathological scores of gastric mucosal tissue such as glandular atrophy, motility, dysplasia mucosal inflammation, and intestinalmetaplasia in the study group were all lower than those in the control group, and all showed statistical differences, P ＜0.05； Thetotal effective rate of clinical treatment in the study group was higher than that in the control group, and the incidence of adversereactions was lower than that in the control group. The differences between the groups were statistically significant, P ＜ 0.05。Conclusion Choosing Banxia Xiexin Tang as the main formula for modified treatment is beneficial for rapidly improving theclinical symptoms and pathological status of gastric mucosal tissue in patients with chronic atrophic gastritis, while further reducingthe influence of inflammatory factors, effectively improving clinical efficacy and safety. It is worth actively promoting asan ideal treatment method in clinical practice. |
| Keywords：Chronic atrophic gastritis; Banxia Xiexin Tang; Conventional Western Medicine |
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